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Ultrasound SmartBrief

Ultrasound markers may indicate abnormal karyotypes

1/20/2026

A retrospective cohort study published in the journal Ultrasound in Obstetrics & Gynecology found that a combination of four ultrasound markers can predict chromosomal abnormalities in early pregnancy with 100% specificity. The markers are a gestational sac mean diameter below the fifth centile, yolk sac mean diameter at or above the 95th centile, crown-rump length below the fifth centile and bradycardia. Medscape (1/16)

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